Research
Research headlines rarely tell the whole story. Start with the study type, who participated, what was measured, and what questions remain.
Research foundations
Learn how evidence develops, then open trusted sources for NF information, published studies, and clinical trials.
Use these labels as a quick guide to how mature the evidence is—not as a guarantee that a finding applies to an individual person.
New to NF research? Begin with the NIH overview, use PubMed to find published literature, and use ClinicalTrials.gov to find registered clinical trials.
Learn about neurofibromatosis, its major types, symptoms, diagnosis, treatment, and current research from the National Institute of Neurological Disorders and Stroke.
National Institutes of Health Find studiesExplore registered neurofibromatosis and schwannomatosis studies, including eligibility, locations, recruitment status, and posted results when available. A trial record alone does not show that a treatment works.
ClinicalTrials.gov Read researchFind biomedical literature about neurofibromatosis and schwannomatosis indexed in PubMed. Review the publication type and study design before relying on a result.
PubMedResearch source directory
Search major U.S. research databases, funding programs, data portals, trial resources, and NF clinical-research programs. A small number of major international sources are included for research that may not appear in U.S. databases.
Find curated NF datasets, model systems, biospecimen resources, and research tools supporting NF and schwannomatosis drug discovery.
Open source Trials & participationBrowse an NF-focused view of active clinical research and treatment development, with links to official U.S. and international trial records.
Open source Clinical research programsExplore NF clinical trials, locally developed research projects, and national collaborations through the hospital’s Multidisciplinary Neurofibromatosis Program.
Open source Clinical research programsReview research studies, clinical-trial work, and NF program updates from a pediatric center involved in multi-institutional NF research.
Open source Clinical research programsFind clinical studies and laboratory research focused on NF-related tumors, plexiform neurofibromas, optic pathway gliomas, and treatment development.
Open source Clinical research programsLearn how Cleveland Clinic’s NF program connects children and adults with clinical trials and research across its neurological, pediatric, and cancer programs.
Open source Funding & projectsReview the federal NF research program’s priorities, funded awards, accomplishments, consumer involvement, and supported clinical research.
Open source Trials & participationSearch public information about clinical trials conducted in the European Union and European Economic Area, including trial documents and locations.
Open source Literature & evidenceSearch international life-sciences literature, full-text articles, preprints, and linked research data alongside records also found in PubMed.
Open source Genetics & regulationConfirm official drug approvals, prescribing information, review documents, safety communications, and regulatory status.
Open source Literature & evidenceRead an expert-authored clinical reference covering NF1 diagnosis, manifestations, management, surveillance, genetics, and counseling.
Open source Genetics & regulationSearch submitted clinical and research genetic tests for NF1, NF2, SMARCB1, LZTR1, and related conditions; confirm current details with the laboratory.
Open source Patient-friendly overviewsStart with a patient-friendly NF overview and follow selected links to genetics, diagnosis, treatment, clinical trials, and trusted health information.
Open source Clinical research programsReview NF-related neuro-oncology care, research expertise, and clinical-trial access through South Carolina’s NCI-designated cancer center.
Open source Clinical research programsExplore NF natural-history studies, clinical research, patient resources, and participation opportunities from the NIH Neurofibromatosis Clinical Team.
Open source Data & research toolsExplore NF1 research programs, shared genomic and tumor data, drug-discovery resources, publications, and collaborative initiatives.
Open source Clinical research programsLearn about the U.S.-coordinated network of primary and affiliate centers conducting clinical trials for NF1, NF2-related schwannomatosis, and other schwannomatoses.
Open source Data & research toolsExplore shared NF1, NF2-related schwannomatosis, and other schwannomatosis datasets, publications, analytical tools, and open-science projects.
Open source Funding & projectsSearch NIH-funded NF research projects, investigators, institutions, award details, abstracts, and linked publications or patents.
Open source Literature & evidenceSearch a free full-text archive of biomedical and life-sciences journal articles, including many NF publications available without a subscription.
Open source Clinical research programsFind NF1- and NF2-related cancer research studies and pediatric or young-adult clinical trials, including studies involving NF-associated low-grade glioma.
Open source Clinical research programsReview research connected with the UAMS Neurofibromatosis Clinic and its work on NF-related tumors, manifestations, and patient care.
Open source Trials & participationSearch across participating international clinical-trial registries to locate studies registered outside the United States.
Open sourceHow to use this directory: Start with original study records, publications, datasets, or government documents whenever possible. A source’s inclusion does not mean every item it contains is clinically proven, current, or appropriate for an individual person.
Explore current activity
See which topics appear across the Hub’s currently retrieved PubMed publications, NIH-funded projects, and ClinicalTrials.gov studies. Select a topic to open the underlying records.
How to read this: Counts show research activity in the limited records currently retrieved by the Hub—not evidence quality, treatment effectiveness, total worldwide research, or how close a topic is to a new treatment. Records may appear in more than one topic. Keyword rules assign topics without an AI API; uncertain items remain under Other emerging research.
Explore where research happens
View U.S. locations connected with a verified NF research program or a study location returned by the Hub’s current ClinicalTrials.gov search.
Matching locations
NF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programChildren’s Hospital of PhiladelphiaPhiladelphia, PA · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programCincinnati Children’s Hospital Medical CenterCincinnati, OH · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programCleveland ClinicCleveland, OH · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programLe Bonheur Children’s Hospital and St. Jude Children’s Research HospitalMemphis, TN · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programMUSC HealthCharleston, SC · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programNational Cancer InstituteBethesda, MD · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programUAMS Adult Neurofibromatosis ClinicLittle Rock, AR · NF1 · NF2-related schwannomatosis · SchwannomatosisNF clinic with a separately maintained research-program or clinical-trial source
Open source Verified research programUniversity of Alabama at BirminghamBirmingham, AL · Confirm with programNF clinic with a separately maintained research-program or clinical-trial source
Open sourceMap boundaries: This is not a complete directory of all NF research. Program markers include only clinics with a separately verified research link. Study markers come from the currently retrieved ClinicalTrials.gov records and may be outdated, inactive, or not recruiting; always confirm the official record. A location on the map does not mean a person is eligible or that an intervention works. Publications and NIH awards are not mapped yet because affiliations and institution names require additional normalization.
Published research
Recently indexed NF and schwannomatosis research articles from PubMed. These are publications, not funding awards or clinical-trial registrations.
Why can a future publication date appear? PubMed may supply an upcoming journal-issue date for an article already available online. Future-dated publications are hidden by default; clear the checkbox above to show them. The Hub retrieves up to 40 recent candidates so filtering does not hide relevant results, displays 12 by default, and lets you continue showing more until every qualifying retrieved publication is visible. The automatic search groups neurofibromatosis OR schwannomatosis and can return matching publications from any institution, including the NF clinics listed above. Use the PubMed link above for the complete result set. Automatically retrieved from PubMed.
Funded research
Active NIH-funded projects whose titles explicitly identify NF, neurofibromatosis, or schwannomatosis. A funding award does not mean a study is complete or has published results.
The automatic NIH RePORTER search treats neurofibromatosis OR schwannomatosis as alternatives, then keeps projects whose titles explicitly identify an NF-related term. Matching awards from listed clinics can appear without a separate clinic feed. Automatically retrieved from NIH RePORTER. Inclusion does not mean a project is complete, clinically proven, or applicable to an individual person.
Research participation
Explore drug and non-drug NF research—including interventional trials, observational research, natural-history studies, and registries—then open the official ClinicalTrials.gov record to confirm eligibility, locations, contacts, and current status.
The ClinicalTrials.gov request groups neurofibromatosis OR schwannomatosis and does not limit results to drug trials. Study categories and research topics are derived from wording in each registered record and may not capture every relevant detail. Matching studies from any sponsor or clinic can appear automatically; eligibility, recruiting locations, and contacts must still be confirmed on the official study record.
Educational exploration
Choose a body system or a whole-person concern to explore possible NF connections, questions researchers study, and reviewed starting points. NF affects every person differently; an item appearing here does not mean that every person with NF will experience it.
Selected starting point
Explore tumors of the brain, spine, and nerves, neurologic changes, headaches, seizures, and related monitoring or research questions.
Browse without the diagram
Explore beyond one body part
Selected starting point
Explore tumors of the brain, spine, and nerves, neurologic changes, headaches, seizures, and related monitoring or research questions.
Reviewed starting points: The body-system and whole-person summaries use current GeneReviews chapters for NF1, NF2-related schwannomatosis, and LZTR1- and SMARCB1-related schwannomatosis. They are navigation aids, not complete lists of manifestations, surveillance recommendations, or treatment guidance.
Learn, play & verify
Take a 20-question knowledge challenge built from reviewed NF and medical sources. Every test includes 15 NF questions, one pop-culture question, one sports question, one algebra question, and two all-ages random questions.
NF questions are based primarily on GeneReviews and other NIH/NLM resources, with CTF, FDA, ClinicalTrials.gov, and other authoritative sources used where appropriate. Question content was last reviewed August 2026.
Ask NF Research
Choose what you want to study. This tool will create a detailed prompt you can copy into ChatGPT or another research assistant. It does not search or answer the question on this website.
Copy prompt is unavailable until you enter what you would like to research.
Enter a research question above to create your prompt.
Copy the finished prompt, then open the assistant you prefer.
Review Research Links
Paste one or more study, trial, article, or research-page links. Select everything you want reviewed, then copy the generated prompt into ChatGPT or another research assistant. This website does not open or analyze the links itself.
Copy prompt is unavailable until you enter at least one complete link beginning with http:// or https://.
Paste one or more research links above to create your review prompt.
Copy the finished prompt, then open the assistant you prefer.
